产品货号：
Z26803
中文名称：
SIGIRR抗体
英文名称：
Anti-SIGIRR Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SIGIRR Antibody |
| 指标别名 | SIGIRR;TIR8;Toll/interleukin 1 receptor 8 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,ICC |
| 基因名称 | SIGIRR |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR.The immunogen is located within the last 50 amino acids of SIGIRR. |
| 计算分子量 | 46kDa |
| 成分 | SIGIRR Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | SIGIRR Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily.Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain.The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family.Similar to ST2,another TIR family member,it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling.However,SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4,TLR5,TLR9,and IL-1R.It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion. |
| Uniprot ID | Q6IA17 |
| 基因名全称 | Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| 蛋白名全称 | Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| 推荐稀释比 | SIGIRR antibody can be used for the detection of SIGIRR by Western blot at 1μg/mL.Antibody can also be used for immunocytochemistry starting at 10μg/mL.Antibody validated:Western Blot in human samples and Immunocytochemistry in human samples.All other applications and species not yet tested. |
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